Trial · NCT07584473
NCWS or IBS/FD in Relatives of CD Patients
Over 50% of non-celiac wheat sensitivity (NCWS) patients are HLA DQ2/DQ8 positive and often have a Celiac Disease (CD) family history. Studies have identified a
- Status
- Recruiting
- Sponsor
- University of Palermo
- Study type
- Interventional
- Phase
- No phase
- Enrollment
- 600 participants (planned)
- Start
- Apr 1, 2026
- Primary completion
- Apr 30, 2027
- Conditions
- Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome), Functional Dyspepsia, Celiac Disease
Summary
Over 50% of non-celiac wheat sensitivity (NCWS) patients are HLA DQ2/DQ8 positive and often have a Celiac Disease (CD) family history. Studies have identified a subgroup of NCWS patients whose clinical and immunological features are closer to CD than to irritable bowel syndrome/functional dyspepsia (IBS/FD) ('inflammatory subgroup'). The investigators hypothesized that among CD patient's relatives, there might be a high number of NCWS subjects, who hypothetically belong to the 'inflammatory subgroup'.
Interventions
- Wheat-Free Diet Other
Locations
1 country: Italy.
| Facility | City | Country |
|---|---|---|
| Celiac Disease and Food Intolerance Clinic, Geriatrics Unit, "P. Giaccone" University Hospital, Palermo | Palermo, PA | Italy |
| Internal Medicine Unit, P.O. "V. Cervello," Ospedali Riuniti "Villa Sofia-Cervello," Palermo | Palermo, PA | Italy |
TreatIBS is an informational site and does not provide medical advice. The research summarized here may not apply to your situation. Talk with a clinician before starting, stopping, or changing any treatment.
Listing only. Eligibility is decided by the study team. TreatIBS is not involved in recruitment.