Trial · NCT06413004
Brachyspira and Intestinal Allergy-like Immune Reactions in Patients With Irritable Bowel Syndrome (IBS)
The aim of this study is to define local immune responses in the GI tract to food antigens in IBS patients, with and without Brachyspira infection, using advanc
- Status
- Recruiting
- Sponsor
- Magnus Simrén
- Study type
- Interventional
- Phase
- No phase
- Enrollment
- 200 participants (planned)
- Start
- Aug 3, 2022
- Primary completion
- Dec 1, 2027
- Conditions
- Irritable Bowel Syndrome, Food Sensitivity
Summary
The aim of this study is to define local immune responses in the GI tract to food antigens in IBS patients, with and without Brachyspira infection, using advanced imaging. We hypothesize that Brachyspira infection can cause IBS symptoms by inducing loss of oral tolerance to dietary antigens through development of food-specific intestinal immune reactions and subsequent development of visceral hypersensitivity.
Interventions
- Elimination and re-introduction of CLE or COLAP positive food item(s) Other
Locations
1 country: Sweden.
| Facility | City | Country |
|---|---|---|
| Mag-tarmlab, Dept of Internal Medicine, Sahlgrenska University Hospital | Gothenburg | Sweden |
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Listing only. Eligibility is decided by the study team. TreatIBS is not involved in recruitment.