Trial · NCT04974593
Predictive Value of Hydrogen/Methane Lactose Breath Testing on the Therapeutic Effect of Lactose-free Diet in Moderate to Severe ROME IV IBS.
Lactose intolerance (LI) results from lactose malabsorption (LM) secondary to insufficient hydrolysis of the disaccharide lactose into galactose and glucose (Mi
- Status
- Recruiting
- Sponsor
- Universitair Ziekenhuis Brussel
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 90 participants (planned)
- Start
- Oct 22, 2021
- Primary completion
- Jan 1, 2028
- Conditions
- Irritable Bowel Syndrome, Lactose Intolerant
Summary
Lactose intolerance (LI) results from lactose malabsorption (LM) secondary to insufficient hydrolysis of the disaccharide lactose into galactose and glucose (Misselwitz 2019). The undigested lactose will eventually reach the colon, resulting in fermentation from colonic bacteria with production of different compounds such as short chain fatty acids, carbon dioxide, H2 and methane (Catanzaro 2021). These compounds have an osmotic effect and can stimulate colonic contractions.
Interventions
- low fat diet Other
Locations
1 country: Belgium.
| Facility | City | Country |
|---|---|---|
| UZ Brussel | Jette, Brussels Capital | Belgium |
TreatIBS is an informational site and does not provide medical advice. The research summarized here may not apply to your situation. Talk with a clinician before starting, stopping, or changing any treatment.
Listing only. Eligibility is decided by the study team. TreatIBS is not involved in recruitment.